DNA damage caused by chemotherapeutic regimens .Whats the differnce in damage caused by mutations ?

An international team led by scientists ar the National Institute of Health is the first to discover a new way that cells form important and dangerous types of DNA damage known as a DNA protein cross link (DPC) . Proteins classified as ZATT has the ability of eliminating DPCs with the help of other proteins (NIH,2017). Since DPCs form when undergoing cancer treatment ; understanding how ZATT along with DPT other proteins work to repair damages caused to DNA structure during cancer treatment is essential in averting said damages . It is fair to note however ; that unlike damages caused to DNA structure by mutations that affect DNA structure  such as 1)duplication 2) nonscence 3) misense 4) insertion   5)framshift ; and 6) deletion ; with deletion being a particularly inciduous form of mutation , these damages are related to treatment process and not a pathological process.

How does it work ?
Researcher Shellenberg explains that often chemotherapeutic drugs  or environmental chemicals block the proteins that allow the structure to retie broken ends   and normalize its allels structure  ; this is largely due to TOP2 which conceals the cut ends within the core of the strand itself ; this is important in reperation because the TOP2 encircles the the DNA strand ; when normal joining of the damaged ends cannot be had permenant damage may occur which in the DNA core ; this in turn  changes the structure all together. This can also be seen as an internal microscopic  scar if you will;  related to chemo and other environmental hazards post  and intra treatment . For this reason This Researcher has stated in the past that securing patient treatment continuum during catastrophic events and natural disasters is so vital to disease prognosis and outcomes .

Implications for Public Health
Unstable TOP2-dpc Complex leads to accumulation of severed DNA that kills cells ;TOP2 remains stuck to the DNA strand hindering its ability to retie itself during chemotherapy and post treatment . The implication of treatment interference , environmental and chemical exposure either through the use of immunomodulators or environmental  hazards must be controlled and monitored when treating a patient with cancer because of the economic burden to the patients ; his or her life expectancy and expectations in remission of pathology , currently a four once of gamma globulin an important derivative of restructuring cells that are transfused to cancer patients can cost up to 60,000 dollars for four ounces; not to mention immunomodulating drugs ; hospital room costs and in many instances job loss and economic bancrupsy from disease diagnosis . Public health  research professionals work in conjunction to Medical researchers to fill in research related knowledge gaps that lead to better treatment outcomes and quality of life

References
NIH (2017) DNA  damage caused by cancer treatment reversed by ZATT protein . National Institute of Health Retrieved from http://www.nih.gov/nes-events/news-release/dna-damage-caused-cancer-treatment-revered-zatt-protein.