Reliable Cancer Diagnosis Specificity and Sensitivity . How Important is it ?

Natural Killer (NK) cells are cytotoxic lymphocytes found in periferal blood that plays a role in host defense and immune regulation .  killer T Cells are the circulatory systems defense mechanism in protecting itself from virus , cocci , and protozoans that invade the circulatory system and colonize to develop infections that cause disease . What happens to these specialized cells when the organism or human body are faced with a disease trajectory such as a cancer diagnosis?.  Especially when NK cells are shown to be associated with an improved prognosis in several cancer such as colorectal cancer ; non  small cell lung cancer and clear cell renal cell carcinoma . Immune modulating cancer medications often used for the treatment of cancer can have a significant impact on the survival of these specialized cells because when practioners decide to administer an  anticancer medication to treat nodule formation concidering that not only do these medications eliminate nodule and neoplasm formation through apoptosis and cell membrane destruction ; but also surrounding cells such as NK cells , hemoglobin , and macrophages . These are a part of the organisms natural defence that include leukocytes as well . Why is choosing correct diagnostic equipment so important in determining treatment outcomes ?  Lets look closer . A growing amount of data has shown that cells cultured in laboratory settings directly impact diagnosis because cell matrix   communication , polarity and in vivo testing ; particularly when using equipment that contain 3 Dimentional  visualization ,define how cells behave , what immune therapeutics are needed to treat this particular nodule or neoplasm  what approach to use . On the other hand testing using 2 Dimentional laboratory equipment does not fully define cell  communication , polarity and or in vivo visualization as precisly as 3 Dimentional

equipment this increases sensitivity and test specificity which influence treatment choice and outcomes.



References

Larson, B Lubna , A & Shroeder, J (2017) Validation Cytotoxicity Assay .3 D Natural Killer Cell Mediated . Lonza Walkersville Inc . Bio Tek